Delivering innovative therapies often involves new ways of working for healthcare systems, including the National Healthcare Service (NHS) in the UK. CAR T-cell therapy is delivered by select treatment centers, which are formally evaluated and accredited. Standards are set by the Joint Accreditation Committee (JACIE) in Europe for consistent quality and safety.¹⁰¹

The UK’s Advanced Therapy Treatment Centre (ATTC) network was set up in 2018, connecting centers delivering Advanced Therapy Medicinal Products (ATMPs) in the UK, including CAR T-cell therapies. It was set up with government funding from Innovate UK,¹⁴³ which is an agency that supports companies’ growth through the development and commercialization of new products and services. The network includes four specialist hubs (see below),¹⁴³ which meet regularly and collaborate across topics such as clinical trials, training and education, patient and public involvement and engagement, patient recruitment and data collection.¹⁴⁶

• Innovate Manchester Advanced Therapy Centre Hub (iMATCH)
• London Advanced Therapies Advanced Therapy Treatment Centre (LAT-ATTC)
• Midlands-Wales Advanced Therapy Treatment Centre (MW-ATTC)
• Northern Alliance Advanced Therapies Treatment Centre (NA-ATTC)¹⁴³

Since its launch, the ATTC network has developed and shared knowledge and practices to support the NHS to deliver advanced therapies.¹⁴³ This has helped make the UK a more attractive place for life sciences investment.¹⁴³ It successfully increased patient access to ATMPs through clinical trial support and improvements to supply chain and logistics. With new funding received in 2024, the network will expand its activities across:¹⁴⁶

• Equity of access to innovative therapies
• Healthcare system readiness for ATMP clinical trials
• Improved ATMP workforce efficiency
• The UK’s attractiveness to sponsors launching ATMP clinical trials
• Economic growth in priority locations in the UK
• Societal benefits from patients treated with ATMPs
• The number of ATMPs approved for use by the NHS